Twinnie's

101 Science Dr, Durham, NC 27710, United States
+1 919-660-3944
$$$ Cafe
(90 Reviews)
Price Range $1–10

If you find yourself near Duke University, Twinnie’s Cafe is an essential stop on your culinary journey. Nestled at 101 Science Dr, Durham, NC, this charming cafe has become a beloved staple for students and locals alike. With its warm ambiance and welcoming staff, Twinnie’s strikes the perfect balance between a casual eatery and a gourmet dining experience. You can reach them at +1 919-660-3944.

At Twinnie’s, the menu is an enticing parade of cafe-style dishes, ensuring that every visit offers something unique to savor. Guests rave about the chicken focaccia, a standout that has captured the hearts and taste buds of many, while the daily specials are crafted with care, showcasing seasonal ingredients and flavors that never disappoint. Whether you’re in the mood for a comforting panini or a refreshing caffeinated beverage, Twinnie’s caters to all cravings with a mix of hearty entrées and delightful drinks. The vibrant drink menu complements their food perfectly, making it easy to find something exciting to wash down your meal.

The atmosphere is invigorating yet relaxed, inviting you to sit back and enjoy your meal. Indoor seating offers a respite from the bustling campus atmosphere, while al fresco options provide a stunning view of the verdant Duke Campus. As noted by Bryan Howell, it’s a wonderful locale to catch up with friends or colleagues over a delicious lunch infused with local charm.

What truly sets Twinnie’s apart, though, is its incredible team. Customers often highlight the exceptional service provided by Jack and his crew, who not only know how to prepare a mean sandwich but also create a friendly, engaging environment. Natalie Chen’s review encapsulates this perfectly, as she mentions the joy of weekly visits and Jack’s fantastic recommendations that make each trip feel special. This kind of interaction transforms a simple cafe visit into an experience where customers feel valued and welcomed.

Additionally, Twinnie’s has garnered acclaim for its selection of desserts, making it an excellent spot for those looking to indulge their sweet tooth after a savory meal. Just as Shelley Willis Queen discovered, the creativity in the kitchen can lead to some unforgettable culinary delights, like the chicken cordon bleu with pottanesca sauce that had her raving about her experience.

For anyone exploring Durham, Twinnie’s Cafe promises more than just a meal—it offers a taste of the local community, genuine hospitality, and a sense of belonging. Don’t miss out on the chance to be part of this vibrant gathering spot; stop by Twinnie’s for a quick bite or linger longer and enjoy the unique offerings that keep loyal customers returning week after week.

Service options
Outdoor seating
Takeaway
Dine-in
Delivery
Highlights
Great coffee
Great tea selection
Popular for
Breakfast
Lunch
Solo dining
Accessibility
Wheelchair-accessible car park
Wheelchair-accessible entrance
Wheelchair-accessible seating
Wheelchair-accessible toilet
Offerings
Coffee
Comfort food
Organic dishes
Prepared foods
Quick bite
Small plates
Vegan options
Vegetarian options
Dining options
Breakfast
Lunch
Dessert
Seating
Table service
Amenities
Toilet
Wi-Fi
Atmosphere
Casual
Cosy
Trendy
Crowd
Groups
University students
Planning
Accepts reservations
Payments
Credit cards
NFC mobile payments
Parking
Free of charge street parking
Openings Hours
Checking

Monday

08:00 AM - 02:30 PM

Tuesday

08:00 AM - 02:30 PM

Wednesday

08:00 AM - 02:30 PM

Thursday

08:00 AM - 02:30 PM

Friday

08:00 AM - 02:30 PM

Saturday

Closed

Sunday

Closed

90 Reviews
Natalie Chen

06 Sep 2025

Twinnie’s has quickly become one of my favorite eateries at Duke! I come here at least once a week and it is always a pleasure to see the team. Special shout out to Jack who never fails to make my day! He is so kind, fun to chat with, and full of great recommendations. The food is top notch (cafe style entrées and drinks); seriously everything here is delicious. I’d recommend trying the daily specials or the classic Chicken Pita. Also, the seasonal pumpkin latte is back! I just drank it for the first time today and it won’t be my last. Check out Twinnie’s for good food and good vibes :)

Jay Dalton

26 Aug 2025

Over the past 12 years I would venture to say that no one has eaten at Twinnies more often than me. The food is always great. The service is always great. Jack, the manager, is always friendly. It's awesome.

Christine Z

27 Jun 2025

I love the sandwiches here. The chicken focaccia is amazing and their specials are usually very good. There's generally a wait during lunch but the line still moves pretty fast.

Shelley Willis Queen

14 Jun 2025

The staff here is fantastic! Always so pleasant and helpful :-) But today... today was by far my best experience: Chef Joe made chicken cordon bleu with pottanesca sauce over rice and it was to die for!!! Thanks for recommending, Jack! You guys do an amazing job and I'm so thankful you're here (though my waistline isn't so happy about it ;-)!

Bryan Howell

13 Jun 2025

A hidden gem near Duke's engineering campus. Paninis, daily specials, and a variety of desserts and coffee make this cafe a nice spot to enjoy a lunch with colleagues and friends, both inside and out. Indoors, you'll find plenty of seating with a nice ambience of the 9-5 in the engineering campus, and outside, you see a beautiful verdant view of Duke's Campus near the hospitals and science labs. Look for Jack. He keeps the place running smoothly and is wonderful to speak to.

Nick Bottenus

05 Jun 2025

Jack and his team run a great little sandwich shop with a big drink menu and a great set of daily specials to add a little variety. From a quick grab and go lunch to on-campus catering needs, they have always been happy to accommodate and are one of the most consistent and convenient eateries on campus.

Join the Twinnie's Newsletter

Get the latest updates on seasonal pastries, special events, and local highlights directly in your inbox.